From proteins to metabolism to cells, we uncover the mechanisms that make the nervous system resilient – or vulnerable – to neurodegeneration.

Our mission

Decode the molecular mechanisms of neuronal resilience. We strive to uncover how certain proteins (such as the ‘TLDc proteins‘), reduction-oxidation (redox) regulation, energy metabolism and communication between cells determine neuronal resilience or vulnerability.

Reprogramme neurodegeneration. By understanding the transition from cellular adaptation to degeneration, we aim to identify new ways to restore resilience in the brain. We explore this in the context of ageing and neurological diseases, including Alzheimer’s disease, dementia with lewy bodies, and TLDc proteins-related diseases.

Translate discoveries from fundamental research into diagnostic tools and treatments for people living with neurological conditions. We are driven by the ambition to identify actionable disease mechanisms and develop new strategies to protect and restore neuronal function, ultimately improving the lives of people living with neurological conditions.

Our Values

Interdisciplinary and collaborative research to tackle big research questions. Since its start in 2020, the Finelli lab has collaborated with over 65 scientists at all career stages, from 30 universities, across 11 countries, in fields spanning molecular and cellular biology, genetics, analytical chemistry, computational science, and clinical research. We have also founded international initiatives such as the International Network for Neurodegenerative Disease Research (part of the Global Alliance of Medical Excellence). Learn about our Projects and the Techniques we use.

Research that benefits people living with neurological conditions and their communities. We firmly hold that research is more impactful when it is informed by the experiences of the individuals it seeks to benefit. We are passionate about discussing our research with people with lived-experience, sharing scientific knowledge with our local communities, and inspiring the next generations of scientists. See our Engagement page.

A culture that fosters an inclusive, respectful, empathetic and supportive environment. We are committed to the continuous development of Early Career Researchers, to help nurture their scientific independence, creativity and confidence. To date, the Finelli group has welcomed 16 scientists from BSc, MSc, and PhD students to postdoctoral researchers. Go to our People page.

Image credit illustrations: ChatGPT / OpenAI.